PREPARATION OF ETHYL-3'-[((7-CHLORO-2-QUINOLINYL)ETHENYL)PHENYL]-3-OXOPROPANOATE, A KEY INTERMEDIATE FOR MONTELUKAST SODIUM

• Main Authors: CHAVA, SATYANARAYANA, GOTTUMUKKALA, VENTAKA, SUBBA, RAJU, CASUKHELA, SOMESWARA, RAO, GORANTLA, SEETA, RAMANJANEYULU
• Format: Patent
• Language: English; French
• Published: 30.06.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

A process for preparing ß- ketoester of formula (III) comprises; (a)condensing alkyl 3- formylbenzoate with 7-Chloroquinaldine to give alkyl 3-[((7-chloro-2-quinolinyl) ethenyl)] benzoate; and (b) reacting alkyl 3-[((7-chloro-2-quinolinyl) ethenyl)] benzoate with an alkyl ester in presence of metal...