METHOD AND SUBSTANCES FOR TREATING HPV INFECTION

• Main Authors: TUNGTEAKKHUN, SANDY, S, FILIPPOVA, MARIA, NEIDIGH, JONATHAN, W, DUERKSEN-HUGHES, PENELOPE, J
• Format: Patent
• Language: English; French
• Published: 15.01.2009
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention is directed to novel polypeptides and compositions capable of binding to the E6 oncoprotein of human papillomavirus (HPV), and to methods of employing the novel polypeptides and compositions of the invention to treat HPV infection. In one aspect, the invention is directed to expression vectors encoding the polypeptides, which contain an E6-binding domain derived from a fragment of FADD, and to host cells containing the vectors. La présente invention concerne de nouveaux polypeptides et compositions capables de se lier à l'oncoprotéine E6 du papillomavirus humain (VPH) et des procédés d'emploi des nouveaux polypeptides et compositions de l'invention pour traiter une infection par le VPH. Sous un aspect, l'invention concerne des vecteurs d'expression codant les polypeptides, qui contiennent un domaine de liaison E6 dérivé d'un fragment FADD, et des cellules hôtes contenant les vecteurs.