THIAZOLE DERIVATIVES AS KINASE INHIBITORS

A series of thiazole derivatives which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, meta...

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Main Authors MACK, STEPHEN ROBERT, BROWN, JULIEN ALISTAIR, CREPY, KAREN VIVIANE LUCILE, ALEXANDER, RIKKI PETER
Format Patent
LanguageEnglish
French
Published 24.04.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract A series of thiazole derivatives which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. La présente invention concerne une série de dérivés de thiazole substitués en position 2 par un groupement morpholin-4-yle substitué. Étant des inhibiteurs sélectifs des enzymes PI3 kinase, ils présentent par conséquent un intérêt en médecine, notamment pour le traitement de pathologies inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.
AbstractList A series of thiazole derivatives which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. La présente invention concerne une série de dérivés de thiazole substitués en position 2 par un groupement morpholin-4-yle substitué. Étant des inhibiteurs sélectifs des enzymes PI3 kinase, ils présentent par conséquent un intérêt en médecine, notamment pour le traitement de pathologies inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.
Author CREPY, KAREN VIVIANE LUCILE
BROWN, JULIEN ALISTAIR
ALEXANDER, RIKKI PETER
MACK, STEPHEN ROBERT
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DocumentTitleAlternate DÉRIVÉS DE THIAZOLE UTILISÉS EN TANT QU'INHIBITEURS DE KINASE
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BROWN, JULIEN ALISTAIR
ALEXANDER, RIKKI PETER
UCB PHARMA S.A
MACK, STEPHEN ROBERT
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Snippet A series of thiazole derivatives which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of P13 kinase...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title THIAZOLE DERIVATIVES AS KINASE INHIBITORS
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