AMIDE INHIBITORS OF LEUKOTRIENE A4 HYDROLASE

• Main Authors: GUILFORD, WILLIAM, CHEN, MING, LIGHT, DAVID, DAVEY, DAVID, KHIM, SEOCK-KYU, YE, HONG, VOGEL, DAVID, YE, BIN, KIRKLAND, THOMAS, KOCHANNY, MONICA, CLARET, EMMANUEL, CLEVE, ARWED, LIANG, AMY, PARKINSON, JOHN, WEI, GUO, PING
• Format: Patent
• Language: English; French
• Published: 27.08.2009
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4a, R4b, R4c, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, R9 and R10 are described herein, or pharmaceutically acceptable salts, solvates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and which are therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of using and preparing the compounds of the invention are also disclosed. La présente invention concerne des composés de formule (I) : dans laquelle r, q, R, R2, R3, R4a, R4b, R4c, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, R9 et R10 sont tels que décrits ici, ou des sels, des solvates, des polymorphes, des ions ammonium, des N-oxydes ou des promédicaments pharmaceutiquement acceptables de ces composés. Lesdits composés sont des inhibiteurs de la leucotriène A4 hydrolase et ils sont donc utilisables pour le traitement des inflammations. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention ainsi que des procédés de préparation et d'utilisation des composés de l'invention.