MODULATION OF THE INTEGRIN LINKED KINASE SIGNALING PATHWAY TO PROMOTE CARDIAC CELL PROLIFERATION AND SELF-RENEWAL

• Main Authors: HANNIGAN, GREGORY, LU, HUANZHANG, COLES, JOHN, G
• Format: Patent
• Language: English; French
• Published: 30.11.2006
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Modulation of the mtegrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infarction (MI) remodeling comprising illiciting an overexpression of ILK, is described The ILK signaling pathway is also used as a means for cardiac stem cell proliferation and self-renewal La modulation de la voie de signalisation de la kinase liée aux intégrines (ILK) est utilisée pour améliorer le processus de remodelage pertinent à une large gamme de maladies cardiaques. Cette invention concerne plus spécifiquement un procédé destiné à favoriser une hypertrophie cardiaque humaine bénéfique ou à produire un remodelage après infarctus du myocarde (MI), ce procédé consistant à déclencher une surexpression de l'ILK. La voie de signalisation de l'ILK sert également de moyen favorisant la prolifération et l'autorenouvellement des cellules souches cardiaques.