DETECTION AND IDENTIFICATION OF BIOPOLYMERS USING FLUORESCENCE QUENCHING
The present invention provides an apparatus for detecting a nanoscale moiety and a method for sensing a nanoscale moiety. The apparatus includes a substrate having a nanopore, at least one excitable molecule attached to the substrate adjacent to the nanopore, and a light source for exciting the exci...
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Main Authors | , , |
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Format | Patent |
Language | English French |
Published |
19.01.2006
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Abstract | The present invention provides an apparatus for detecting a nanoscale moiety and a method for sensing a nanoscale moiety. The apparatus includes a substrate having a nanopore, at least one excitable molecule attached to the substrate adjacent to the nanopore, and a light source for exciting the excitable molecule attached to the substrate adjacent to the nanopore wherein the excitable molecule is quenched by the quencher molecule on the nanoscale moiety as it passes by the excitable molecule. The invention also includes a method for detecting the presence or identity of the nanoscale moiety.
L'invention concerne un dispositif et un procédé pour détecter une fraction nanométrique. Ce dispositif comprend un substrat présentant un nanopore, au moins une molécule excitable fixée sur le substrat de manière adjacente au nanopore, et une source de lumière servant à exciter la molécule excitable fixée au substrat de manière adjacente au nanopore, ladite molécule excitable étant éteinte par la molécule d'extinction présente sur la fraction nanométrique lorsqu'elle passe devant la molécule excitable. L'invention concerne également un procédé pour détecter la présence ou l'identité d'un fraction nanométrique. |
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AbstractList | The present invention provides an apparatus for detecting a nanoscale moiety and a method for sensing a nanoscale moiety. The apparatus includes a substrate having a nanopore, at least one excitable molecule attached to the substrate adjacent to the nanopore, and a light source for exciting the excitable molecule attached to the substrate adjacent to the nanopore wherein the excitable molecule is quenched by the quencher molecule on the nanoscale moiety as it passes by the excitable molecule. The invention also includes a method for detecting the presence or identity of the nanoscale moiety.
L'invention concerne un dispositif et un procédé pour détecter une fraction nanométrique. Ce dispositif comprend un substrat présentant un nanopore, au moins une molécule excitable fixée sur le substrat de manière adjacente au nanopore, et une source de lumière servant à exciter la molécule excitable fixée au substrat de manière adjacente au nanopore, ladite molécule excitable étant éteinte par la molécule d'extinction présente sur la fraction nanométrique lorsqu'elle passe devant la molécule excitable. L'invention concerne également un procédé pour détecter la présence ou l'identité d'un fraction nanométrique. |
Author | DOHERTY, THOMAS, P VERDONK, EDWARD, D PITTARO, RICHARD, J |
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DocumentTitleAlternate | DETECTION ET IDENTIFICATION DE BIOPOLYMERES PAR EXTINCTION DE FLUORESCENCE |
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Snippet | The present invention provides an apparatus for detecting a nanoscale moiety and a method for sensing a nanoscale moiety. The apparatus includes a substrate... |
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SubjectTerms | CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEASURING NANOTECHNOLOGY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TESTING TRANSPORTING |
Title | DETECTION AND IDENTIFICATION OF BIOPOLYMERS USING FLUORESCENCE QUENCHING |
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