PEPTIDES

• Main Authors: CHAN, WENG, C, ATKINSON, GAIL, E, ZHELEVA, DANIELLA, I, MCINNES, CAMPBELL, ANDREWS, MARTIN, J., I, FISCHER, PETER, M
• Format: Patent
• Language: English; French
• Published: 06.05.2005
• Edition: 7
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The present invention relates to p2l derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p2l. and display selectivity for cyclin/CDK2 inhibition over cy...