Compositions of lipopeptide antibiotic derivativesand methods of use thereof

The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatme...

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Main Authors CHEN, YUCHEN, NODWELL, MATTHEW, LEESE, RICHARD, A, CURRAN, WILLIAM, V, BOYD, VINCENT, A, CAMERON, DALE, R, BORDERS, DONALD, B, CADUGOURD, DOMINIQUE, WACOWICH-SGARBI, SHIRLEY, A, SGARBI, PAULO, W. M, JIA, QI
Format Patent
LanguageEnglish
Published 08.06.2006
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections. La présente invention concerne des dérivées d'antibiotiques de la classe des lipopeptides possédant une activité antimicrobienne contre les micro-organismes, des méthodes et des composés destinés à la synthèse de ces dérivés antimicrobiens et de produits analogues, ainsi que des méthodes d'utilisation de ces composés dans divers contextes, y compris dans le traitement et la prévention d'infections microbiennes.
Bibliography:Application Number: WO2004US21039