METHODS AND MEANS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH CELLULAR SENESCENCE

• Main Authors: D'ADDAFAGAGNA, FABRIZIO, REAPER, PHILIP, MICHAEL, JACKSON, STEPHEN
• Format: Patent
• Language: English; French
• Published: 11.11.2004
• Edition: 7
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage check...