PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME
A process for industrially advantageously producing a steroid C17,20-lyase inhibitor represented by the following general formula (I); and a Reformatsky reagent in a stable form which is suitable for use in the production process. Either a specific ß-hydroxy ester compound derivative obtained from a...
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Main Authors | , , , , |
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Format | Patent |
Language | English French Japanese |
Published |
24.07.2003
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Abstract | A process for industrially advantageously producing a steroid C17,20-lyase inhibitor represented by the following general formula (I); and a Reformatsky reagent in a stable form which is suitable for use in the production process. Either a specific ß-hydroxy ester compound derivative obtained from a specific carbonyl compound by the Reformatsky reaction or a salt of the compound is reduced in the presence of a metal/hydrogen complex compound and a metal halide and then subjected to ring closure to thereby obtain a compound represented by the general formula (I): (I) wherein the symbols have the same meanings as defined in the description. In the Reformatsky reaction, a stable solution of the compound represented by BrZnCH2COOC2H5 or crystals of the compound represented by (BrZnCH2COOC2H5.THF)2 are useful.
L'invention concerne un procédé industriel avantageux pour l'élaboration d'inhibiteur de C17, 20 - lyase stéroïde représenté par la formule générale (I); et un réactif de Reformatsky sous forme stable, approprié à l'utilisation dans le processus de production correspondant. L'opération consiste à réduire un dérivé de composé de beta -hydroxy ester spécifique issu d'un composé carbonyle spécifique, par la réaction de Reformatsky, ou un sel correspondant du composé, en présence de composé de complexe métal/hydrogène et d'un halogénure de métal, que l'on soumet ensuite à une cyclisation, donnant un composé représenté par la formule générale (I). Pour les besoins de ladite formule, les symboles sont tels que définis dans la description. S'agissant de la réaction de Reformatsky, une solution stable du composé représenté par BrZnCH2COOC2H5, ou des cristaux du composé représenté par (BrZnCH2COOC2H5.THF)2, sont utiles. |
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AbstractList | A process for industrially advantageously producing a steroid C17,20-lyase inhibitor represented by the following general formula (I); and a Reformatsky reagent in a stable form which is suitable for use in the production process. Either a specific ß-hydroxy ester compound derivative obtained from a specific carbonyl compound by the Reformatsky reaction or a salt of the compound is reduced in the presence of a metal/hydrogen complex compound and a metal halide and then subjected to ring closure to thereby obtain a compound represented by the general formula (I): (I) wherein the symbols have the same meanings as defined in the description. In the Reformatsky reaction, a stable solution of the compound represented by BrZnCH2COOC2H5 or crystals of the compound represented by (BrZnCH2COOC2H5.THF)2 are useful.
L'invention concerne un procédé industriel avantageux pour l'élaboration d'inhibiteur de C17, 20 - lyase stéroïde représenté par la formule générale (I); et un réactif de Reformatsky sous forme stable, approprié à l'utilisation dans le processus de production correspondant. L'opération consiste à réduire un dérivé de composé de beta -hydroxy ester spécifique issu d'un composé carbonyle spécifique, par la réaction de Reformatsky, ou un sel correspondant du composé, en présence de composé de complexe métal/hydrogène et d'un halogénure de métal, que l'on soumet ensuite à une cyclisation, donnant un composé représenté par la formule générale (I). Pour les besoins de ladite formule, les symboles sont tels que définis dans la description. S'agissant de la réaction de Reformatsky, une solution stable du composé représenté par BrZnCH2COOC2H5, ou des cristaux du composé représenté par (BrZnCH2COOC2H5.THF)2, sont utiles. |
Author | MIKI, SHOKYO NUWA, SHIGERU HANDA, SYOJI NAKAMOTO, KOJI KAWAKAMI, JUN-ICHI |
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DocumentTitleAlternate | PROCEDE RELATIF A L'ELABORATION DE COMPOSE D'IMIDAZOLE FONDU, REACTIF DE REFORMATSKY SOUS FORME STABLE, ET PROCEDE D'ELABORATION CORRESPONDANT |
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RelatedCompanies | MIKI, SHOKYO TAKEDA CHEMICAL INDUSTRIES, LTD NUWA, SHIGERU HANDA, SYOJI NAKAMOTO, KOJI KAWAKAMI, JUN-ICHI |
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Snippet | A process for industrially advantageously producing a steroid C17,20-lyase inhibitor represented by the following general formula (I); and a Reformatsky... |
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SubjectTerms | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME |
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