THE POLYESTER CONTAINING ACTIVE DRUGS AND HAVING AMINO ACIDS IN THE MAIN CHAIN, AND ITS PREPARATION METHOD

• Main Authors: RAO, JU, TANG, ZHIRONG, CHENG, SHUJUN
• Format: Patent
• Language: Chinese; English; French
• Published: 22.05.2003
• Edition: 7
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

The present invention discloses the polyester containing active drugs and having amino acids in the main chain, and its preparation method. The said drug is the polymer having the following general structural formula: I wherein R1 represents serine, aspartic acid, glutamic acid or lysine R2 represents the drug having reactive groups. The preparation of the polymer includes the three steps: the polymerization between the lactide or lactone and the derivative of morpholine-dione of the amino acids containing multifunctional groups the removal of the protection and the bonding with the drugs. The present invention incorporates the natural amino acids containing multifunctional groups into the biodegradable polyester randomly, thus avoid the antigenicity of the catabolite, at the same time the catabolite may be biological absorbed completely. The polyester contains active groups such as carboxyl, hydroxyl and amino etc, the resulting drug polymer may take effect directly, or may take effect after the degradation.