COMBINATIONS OF ANTIBODIES SELECTIVE FOR A TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR AND OTHER THERAPEUTIC AGENTS

• Main Authors: KOOPMAN, WILLIAM, J, ICHIKAWA, KIMIHISA, ZHOU, TONG, OSHUMI, JUN, KIMBERLY, ROBERT, P, LOBUGLIO, ALBERT, F, BUCHSBAUM, DONALD, J
• Format: Patent
• Language: English; French
• Published: 08.05.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth. L'invention porte sur un anticorps ayant une interaction avec le récepteur DR5 ou DR4 humain et générant des effets agonistes ou antagonistes en aval du récepteur, cet anticorps permettant d'inhiber la prolifération cellulaire et l'apoptose. L'invention porte également sur des procédés de production et d'utilisation des anticorps, éventuellement en combinaison avec divers agents thérapeutiques, notamment dans le traitement de maladies relatives à l'apoptose et de la prolifération cellulaire anarchique.