RENIN AND/OR PROPRENIN RECEPTOR PROTEIN, NUCLEIC ACID CODING FOR SAME AND USES THEREOF

• Main Authors: SRAER, JEAN-DANIEL, NGUYEN, GENEVIEVE, DELARUE, FRANCOISE
• Format: Patent
• Language: English; French
• Published: 10.05.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention concerns an isolated protein with renin receptor activity, a nucleic acid coding for said protein and their uses, in particular for screening antagonists or agonists of the renin-receptor linkage, useful in particular for treating diseases involving the renin/angiotensin system, and affecting in particular the heart, the kidneys and the brain. Cette invention concerne une protéine isolée à activité de récepteur de la rénine, un acide nucléique codant pour cette protéine et leurs applications, notamment pour le criblage de composés antagonistes ou agonistes de la liaison rénine-récepteur, utiles notamment dans le traitement d'affections impliquant le système rénine/angiotensine, et atteignant en particulier le coeur, les reins et le cerveau.