HUMAN KININOGEN D5 DOMAIN POLYPEPTIDES AND THEIR USE

• Main Authors: MAZAR, ANDREW, P, JUAREZ, JOSE, C
• Format: Patent
• Language: English; French
• Published: 12.09.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Peptides form the human kininogen D5 domain and fusion peptides thereof having angiogenesis-inhibitory activity. These peptides are used in diagnosis and therapy of diseases associated with endothelial cell migration and proliferation, e.g., the treatment of cancer. The invention further relates to nucleic acid molecules encoding said peptides, antibodies to the said peptides and methods for isolating said peptides and cells expressing them. Cette invention a trait à des peptides issus du domaine D5 humain de production de kinine ainsi qu'aux peptides hybrides de celui-ci, lesquels ont une action inhibitrice de l'angiogenèse. On utilise ces peptides pour le diagnostic et le traitement d'états pathologiques associés à une migration et à une prolifération des cellules endothéliales, notamment pour le traitement du cancer. L'invention concerne également des molécules d'acide nucléique codant ces peptides, des anticorps contre ces peptides, des cellules exprimant ces peptides ainsi que des procédés d'isolation de ceux-ci.