TRANSGENIC MOUSE FOR SCREENING AND FOR STUDIES OF THE PHARMACODYNAMICS AND PHARMACOKINETICS OF LIGANDS ACTING ON THE OESTROGEN RECEPTOR AND ITS INTRACELLULAR RECEPTORS, AND METHOD FOR THE PREPARATION THEREOF

• Main Authors: CIANA, PAOLO, MAGGI, ADRIANA, CATERINA
• Format: Patent
• Language: English; French
• Published: 18.04.2002
• Edition: 7
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TESTING; TRAPPING; VINEGAR; WINE

The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilising a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse. Cette invention concerne un procédé de production d'un mammifère transgénique non humain permettant de surveiller, in vivo et dans tous les tissus, l'état d'activation de tout récepteur intracellulaire au moyen d'un gène rapporteur induisible par des molécules naturelles ou synthétiques modulant l'activité dudit récepteur. Le mammifère en question est de préférence une souris.