CYK-4 POLYPEPTIDES, DNA MOLECULES ENCODING THEM AND THEIR USE IN SCREENING METHODS

• Main Authors: JANTSCH-PLUNGER, VERENA, GLOTZER, MICHAEL, KAITNA, SUSANNE, ROMANO, ALPER, MISHIMA, MASANORI
• Format: Patent
• Language: English; French
• Published: 05.12.2002
• Edition: 7
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; TRAPPING; VINEGAR; WINE

Mammalian CYK-4 polypeptides, which are key molecules required for cytokinesis, and DNA molecules encoding them. Screening methods based on biochemical reactions relevant for the function of CYK-4 can be employed to identify compounds interfering with cell division. Such compounds are useful in tumour therapy. L'invention concerne des polypeptides CYK-4 étant des molécules clé nécessaires à la cytocinèse, ainsi que des molécules d'ADN codant ces polypeptides. Des procédés de criblage reposant sur des réactions biochimiques nécessaires à l'activité de CYK-4 peuvent être employés afin d'identifier des composés interférant avec la division cellulaire. De tels composés servent au traitement des tumeurs.