DIHYDRO-2H-NAPHTHALENE-1-ONE INHIBITORS OF RAS FARNESYL TRANSFERASE

The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and ps...

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Bibliographic Details
Main Authors REPINE, JOSEPH, THOMAS, REWCASTLE, GORDON, WILLIAM, LEONARD, DANIELE, MARIE
Format Patent
LanguageEnglish
French
Published 23.05.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme. La présente invention concerne des dihydro-2H-naphtalène-1-ones et des sels, des esters, des amides et des promédicaments pharmaceutiquement acceptables desdits composés, lesquels sont utiles pour traiter et prévenir une prolifération incontrôlée ou anormale de tissus, telle que le cancer, l'athérosclérose, la resténose et le psoriasis. Plus particulièrement, la présente invention se rapporte à des composés inhibant l'enzyme farnésyltransférase.
Bibliography:Application Number: WO2001US12433