PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF

• Main Authors: SLEGERS, HERMAN, HAVLI&CCARON, KRY&SCARON, ESMANS, EDGARD, BERNEMAN, ZWI, NISAN, STRNAD, MIROSLAV, SIGLEROVA, VERA, VAN ONCKELEN, HENRI, VERMEULEN, KATRIEN, LENOBEL, RENE
• Format: Patent
• Language: English; French
• Published: 04.10.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

2-, 6-, 8-, 9-monosubstituted, 2,6-, 2,9-, 6,8-, 6,9-disubstituted and 2,6,8-, 2,6,9-, 6,8,9-trisubstituted purine derivatives and their deaza- and aza- analogues with an inhibitor effect with respect to cyclin-dependent kinase proteins (cdks). Their use as anticancer, anti-inflammatory, antiviral,...