MODIFIED LEUKOTOXIN GENE AND PROTEIN

The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolyti...

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Bibliographic Details
Main Authors STROMMER, JUDITH, N, LEE, RAYMOND, W., H, LO, REGGIE, Y., C, HODGINS, DOUG, SHEWEN, PATRICIA, E
Format Patent
LanguageEnglish
French
Published 10.01.2002
Edition7
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals. La présente invention concerne des séquences d'acide nucléique codant pour une leucotoxine modifiée, dans laquelle les modifications comprennent la suppression de séquences d'acides nucléiques codant pour des acides aminés au sein des domaines transmembranaires hydrophobes de la leucotoxine pleine longueur, de préférence de Mannheimia haemolytica. Les leucotoxines modifiées sont utiles dans la formulation de vaccins efficaces contre Mannheimia haemolytica chez les animaux.
Bibliography:Application Number: WO2000CA01498