METHOD OF EVALUATING MYELOSUPPRESSIVE STATE

• Main Authors: BLUMENTHAL, ROSALYN, D, GOLDENBERG, DAVID, M, YING, ZHILIANG, ALISAUSKAS, RITA, JUWEID, MALIK, LEW, WALTER
• Format: Patent
• Language: English; French
• Published: 03.08.2000
• Edition: 7
• Subjects: CHEMISTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; TECHNICAL SUBJECTS COVERED BY FORMER USPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS; TESTING

The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective dose. L'invention concerne des trousses et des procédés permettant d'évaluer l'état myélodépressif d'un patient. Ces procédés et trousses constituent un complément utile à des thérapies cytotoxiques et myélodépressives. L'établissement de taux seuils de certaines cytokines représentant l'état de dépression médullaire permet d'optimiser les protocoles de traitement en vue de réduire la myélotoxicité, tout en maximisant la dose efficace.