TRANSGENIC NONHUMAN MAMMAL AND USES THEREOF TO IDENTIFY COMPOUNDS USEFUL FOR IMPROVING LONG-TERM MEMORY
The present invention provides for a transgenic nonhuman mammal whose germ or somatic cells contain a nucleic acid molecule which encodes calcineurin or a variant thereof under the control of a regulatable promoter, introduced into the mammal, or an ancestor thereof, at an embryonic stage. The prese...
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Main Authors | , , , , |
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Format | Patent |
Language | English French |
Published |
24.02.2000
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Abstract | The present invention provides for a transgenic nonhuman mammal whose germ or somatic cells contain a nucleic acid molecule which encodes calcineurin or a variant thereof under the control of a regulatable promoter, introduced into the mammal, or an ancestor thereof, at an embryonic stage. The present invention also provides for a method of evaluating whether a compound is effective in improving long-term memory in a subject suffering from impaired long-term memory which comprises: (a) administering the compound to the transgenic nonhuman mammal of claim 1 wherein the mammal has increased brain-specific calcineurin activity due to expression of the nucleic acid, and (b) comparing the long-term memory of the mammal in step (a) with the long-term memory of the mammal in the absence of the compound so as to determine whether the compound is effective in rescuing the long-term memory defect in the subject.
La présente invention concerne un animal transgénique dont les cellules germinatives ou somatiques contiennent une molécule d'acide nucléique codant la calcineurine, ou une variante de celle-ci, sous le contrôle d'un promoteur pouvant être régulé, introduit dans l'animal, ou dans un de ses ancêtres, à un stade embryonnaire. Par ailleurs, cette invention concerne un procédé permettant d'évaluer si un composé peut efficacement améliorer la mémoire à long terme chez un sujet souffrant de troubles de la mémoire à long terme; ce procédé consistant à: (a) administrer le composé en question à l'animal transgénique de la revendication (1), cet animal présentant une activité calcineurinique élevée spécifique du cerveau en raison de l'expression de l'acide nucléique, et (b) comparer la mémoire à long terme de cet animal lors de l'étape (a) avec sa mémoire à long terme en l'absence du composé précité, de manière à déterminer si ce composé est réellement efficace dans le recouvrement de la mémoire à long terme chez ce sujet. |
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AbstractList | The present invention provides for a transgenic nonhuman mammal whose germ or somatic cells contain a nucleic acid molecule which encodes calcineurin or a variant thereof under the control of a regulatable promoter, introduced into the mammal, or an ancestor thereof, at an embryonic stage. The present invention also provides for a method of evaluating whether a compound is effective in improving long-term memory in a subject suffering from impaired long-term memory which comprises: (a) administering the compound to the transgenic nonhuman mammal of claim 1 wherein the mammal has increased brain-specific calcineurin activity due to expression of the nucleic acid, and (b) comparing the long-term memory of the mammal in step (a) with the long-term memory of the mammal in the absence of the compound so as to determine whether the compound is effective in rescuing the long-term memory defect in the subject.
La présente invention concerne un animal transgénique dont les cellules germinatives ou somatiques contiennent une molécule d'acide nucléique codant la calcineurine, ou une variante de celle-ci, sous le contrôle d'un promoteur pouvant être régulé, introduit dans l'animal, ou dans un de ses ancêtres, à un stade embryonnaire. Par ailleurs, cette invention concerne un procédé permettant d'évaluer si un composé peut efficacement améliorer la mémoire à long terme chez un sujet souffrant de troubles de la mémoire à long terme; ce procédé consistant à: (a) administrer le composé en question à l'animal transgénique de la revendication (1), cet animal présentant une activité calcineurinique élevée spécifique du cerveau en raison de l'expression de l'acide nucléique, et (b) comparer la mémoire à long terme de cet animal lors de l'étape (a) avec sa mémoire à long terme en l'absence du composé précité, de manière à déterminer si ce composé est réellement efficace dans le recouvrement de la mémoire à long terme chez ce sujet. |
Author | WINDER, DANNY, G MANSUY, ISABELLE, M BACH, MARY, ELIZABETH MAYFORD, MARK KANDEL, ERIC, R |
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DocumentTitleAlternate | ANIMAL TRANSGENIQUE ET SES UTILISATIONS POUR L'IDENTIFIER DES COMPOSES UTILISES POUR AMELIORER LA MEMOIRE A LONG TERME |
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Snippet | The present invention provides for a transgenic nonhuman mammal whose germ or somatic cells contain a nucleic acid molecule which encodes calcineurin or a... |
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SubjectTerms | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING TRAPPING VINEGAR WINE |
Title | TRANSGENIC NONHUMAN MAMMAL AND USES THEREOF TO IDENTIFY COMPOUNDS USEFUL FOR IMPROVING LONG-TERM MEMORY |
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