Glycosidase inhibitors and uses thereof

The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to defi...

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Bibliographic Details
Main Authors Kaul Ramesh, Liu Kun, Chang Jiang, Selnick Harold G, Wei Zhongyong, Wang Yaode, McEachern Ernest J
Format Patent
LanguageEnglish
Published 10.04.2018
Subjects
ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR
CHEMISTRY
CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS,e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES,DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS
CONVEYING
HANDLING THIN OR FILAMENTARY MATERIAL
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PACKAGES
PACKAGING ELEMENTS
PACKING
PERFORMING OPERATIONS
STORING
TRANSPORTING
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Summary:The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Bibliography:Application Number: US201314655222