Quinazoline compounds and their use in therapy

• Main Authors: Caron Joachim, Sun Aiming, Ganesh Thota, Liu Jin, Chapman-Rothe Nadine, Brown Robert, Snyder James, Fuchter Matthew John, Srimongkolpithak Nitipol
• Format: Patent
• Language: English
• Published: 03.04.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of EZH2 provides a therapeutic or prop...