Functional polymer film-coated particle having high drug content, tablet containing same, and methods for production thereof
Provided are functional drug-containing particles which can be compressed into tablets and in particular, to orally disintegrating tablets by employing any of a dry molding method, a wet molding method, or a humidifying drying method. The functional drug-containing particles comprise substantially s...
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Format | Patent |
Language | English |
Published |
04.07.2017
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Abstract | Provided are functional drug-containing particles which can be compressed into tablets and in particular, to orally disintegrating tablets by employing any of a dry molding method, a wet molding method, or a humidifying drying method. The functional drug-containing particles comprise substantially spherical drug-containing particles essentially including drug and a binder, the functional drug-containing particles including a functional polymer film selected from the group consisting of an enteric film, a release control film, and a bitter taste masking film, an average particle diameter of said functional drug-containing particles being 400 μm or less, a particle diameter ratio D90/D10 of the functional drug-containing particles with respect to particle size distribution calculated on a volumetric basis being 1.65 or more, or a coefficient of variation in particle diameters being 24% or more. |
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AbstractList | Provided are functional drug-containing particles which can be compressed into tablets and in particular, to orally disintegrating tablets by employing any of a dry molding method, a wet molding method, or a humidifying drying method. The functional drug-containing particles comprise substantially spherical drug-containing particles essentially including drug and a binder, the functional drug-containing particles including a functional polymer film selected from the group consisting of an enteric film, a release control film, and a bitter taste masking film, an average particle diameter of said functional drug-containing particles being 400 μm or less, a particle diameter ratio D90/D10 of the functional drug-containing particles with respect to particle size distribution calculated on a volumetric basis being 1.65 or more, or a coefficient of variation in particle diameters being 24% or more. |
Author | Hizaki Masaya Hayashida Tomohiro Kinoshita Naotoshi Yamazaki Junji Nakano Yoshio |
Author_xml | – fullname: Kinoshita Naotoshi – fullname: Hizaki Masaya – fullname: Nakano Yoshio – fullname: Hayashida Tomohiro – fullname: Yamazaki Junji |
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RelatedCompanies | POWEREX CORPORATION POWREX CORPORATION ZENSEI PHARMACUETICAL INDUSTRIES CO., LTD ZENSEI PHARMACEUTICAL INDUSTRIES CO., LTD |
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Snippet | Provided are functional drug-containing particles which can be compressed into tablets and in particular, to orally disintegrating tablets by employing any of... |
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Title | Functional polymer film-coated particle having high drug content, tablet containing same, and methods for production thereof |
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