Combination therapy to treat Mycobacterium diseases

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either...

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Bibliographic Details
Main Authors Le Tiran Arnaud, O'Dowd Hardwin, Bennani Youssef Laafiret, Grillot Anne-Laure, Locher Christopher Phillip, Charifson Paul S, Perola Emanuele
Format Patent
LanguageEnglish
Published 21.02.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
Bibliography:Application Number: US201313942342