Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates

Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve admi...

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Main Authors Veiseh Omid, Ma Minglin, Doloff Joshua Charles, Chen Delai, Vegas Arturo Jose, Langer Robert S, Anderson Daniel G, Kastrup Christian J
Format Patent
LanguageEnglish
Published 31.01.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
AbstractList Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
Author Anderson Daniel G
Veiseh Omid
Chen Delai
Vegas Arturo Jose
Ma Minglin
Kastrup Christian J
Langer Robert S
Doloff Joshua Charles
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– fullname: Kastrup Christian J
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RelatedCompanies The Children's Medical Center Corporation
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
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Snippet Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
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