Salt form of a multi-arm polymer-drug conjugate

Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the correspondin...

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Main Authors NIE SHAOYONG, HANDLEY JOHN R, MCMANUS SAMUEL P, SPENCE PATRICK L, LAVATY GREG, CHONG ANTHONY O, SWALLOW DAVID, BRAY BRIAN, KOZLOWSKI ANTONI, SCHAEFER ANTHONY G, JOSHI BHALCHANDRA V, LEE SEOJU, TIPNIS SACHIN
Format Patent
LanguageEnglish
Published 05.01.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
COMPOSITIONS BASED THEREON
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Abstract Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.
AbstractList Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.
Author JOSHI BHALCHANDRA V
KOZLOWSKI ANTONI
SWALLOW DAVID
NIE SHAOYONG
LEE SEOJU
LAVATY GREG
CHONG ANTHONY O
MCMANUS SAMUEL P
SPENCE PATRICK L
HANDLEY JOHN R
BRAY BRIAN
TIPNIS SACHIN
SCHAEFER ANTHONY G
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– fullname: SWALLOW DAVID
– fullname: BRAY BRIAN
– fullname: KOZLOWSKI ANTONI
– fullname: SCHAEFER ANTHONY G
– fullname: JOSHI BHALCHANDRA V
– fullname: LEE SEOJU
– fullname: TIPNIS SACHIN
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Snippet Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of...
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SubjectTerms ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
COMPOSITIONS BASED THEREON
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
Title Salt form of a multi-arm polymer-drug conjugate
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