3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use

• Main Authors: ELLIOT RICHARD JAMES ROWLAND, PORTER RODERICK, BAYFORD MELANIE JAYNE, PERRIOR TREVOR ROBERT, KEY REBEKAH ELISABETH, LORD CHRISTOPHER JAMES, ASHWORTH ALAN, NICULESCU-DUVAZ DAN, JARVIS ASHLEY NICHOLAS, FIRTH-CLARK STUART, BOFFEY RAYMOND JOHN
• Format: Patent
• Language: English
• Published: 24.11.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2H-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.) and/or Wnt signalling. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.); to inhibit Wnt signalling; to treat disorders that are ameliorated by the inhibition of PARP (e.g., PARP1, TNKS1, TNKS2, etc.); to treat disorders that are ameliorated by the inhibition of Wnt signalling; to treat proliferative conditions such as cancer, etc.