Pyrimidyl cyclopentanes as AKT protein kinase inhibitors

• Main Authors: SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, LI JUN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
• Format: Patent
• Language: English
• Published: 30.09.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for...