Triazole derivatives for treatment of Alzheimer's disease

According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of Abeta42 and hence are useful in treatment of Alzheimer's disease and...

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Main Authors KATTAR SAM, ZHOU HUA, CHICHETTI STEPHANIE, SCHELL ADAM J, MUNOZ BENITO, METHOT JOEY, BROWN WILLIAM COLBY, AHEARN SEAN P, RIVKIN ALEXEY A, ROSENAU ANDREW, FISCHER CHRISTIAN, CHRISTOPHER MATTHEW, LI CHAOMIN, MACCOSS RACHEL N
Format Patent
LanguageEnglish
Published 05.11.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of Abeta42 and hence are useful in treatment of Alzheimer's disease and related conditions.
AbstractList According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of Abeta42 and hence are useful in treatment of Alzheimer's disease and related conditions.
Author CHRISTOPHER MATTHEW
ROSENAU ANDREW
BROWN WILLIAM COLBY
MACCOSS RACHEL N
METHOT JOEY
AHEARN SEAN P
LI CHAOMIN
CHICHETTI STEPHANIE
MUNOZ BENITO
KATTAR SAM
FISCHER CHRISTIAN
RIVKIN ALEXEY A
SCHELL ADAM J
ZHOU HUA
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– fullname: BROWN WILLIAM COLBY
– fullname: AHEARN SEAN P
– fullname: RIVKIN ALEXEY A
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– fullname: CHRISTOPHER MATTHEW
– fullname: LI CHAOMIN
– fullname: MACCOSS RACHEL N
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ROSENAU ANDREW
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SCHELL ADAM J
ZHOU HUA
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HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title Triazole derivatives for treatment of Alzheimer's disease
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