Photoreactive regulator of protein function and methods of use thereof

• Main Authors: VOLGRAF MATTHEW, LANGA PABLO IGNACIO GOROSTIZA, BANGHART MATTHEW, ISACOFF EHUD Y, BORGES KATHARINE, TRAUNER DIRK, KRAMER RICHARD H
• Format: Patent
• Language: English
• Published: 14.02.2012
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ELECTROTHERAPY; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MAGNETOTHERAPY; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; RADIATION THERAPY; SPIRITS; TESTING; ULTRASOUND THERAPY; VINEGAR; WINE

The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.