6-oxo-1,6-dihydropyridine compounds as inhibitors of MEK and methods of use thereof

• Main Authors: MARLOW ALLISON L, WALLACE ELI M, LYSSIKATOS JOSEPH P, BLAKE JAMES, YANG HONG-WOON, SEO JEONGBEOB
• Format: Patent
• Language: English
• Published: 24.01.2012
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and...