Treatment methods using Dkk-1 antibodies

• Main Authors: LI JI, SHEN WENYAN, RICHARDS WILLIAM GLEASON, LU HSIENG SEN
• Format: Patent
• Language: English
• Published: 24.01.2012
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing suc...