Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8, and R8a are...

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Main Authors SUN SHAOYI, SEID BAGHERZADEH MEHRAN, CHAKKA NAGASREE, KODUMURU VISHNUMURTHY, CHOWDHURY SULTAN, KAMBOJ RAJENDER, FU JIANMIN, SVIRIDOV SERGUEI, RAINA VANDNA, LIU SHIFENG, ZHANG ZAIHUI, HOU DUANJIE
Format Patent
LanguageEnglish
Published 31.05.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8, and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Bibliography:Application Number: US20050575639