Phthalazine compounds and methods of use

• Main Authors: CHAKRABARTI PARTHA PRATIM, XU SHIMIN, FALSEY JAMES RICHARD, TASKER ANDREW, REED ANTHONY, CAO GUO-QIANG, HERBERICH BRADLEY J, PETTUS LIPING H, RZASA ROBERT M, HUNGATE RANDALL W, ZHANG DAWEI, SHAM KELVIN K. C, THAMAN MAYA C
• Format: Patent
• Language: English
• Published: 20.07.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein B, R1, R2, R3, R4 and R5 are d.efined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.