Combinations of antibodies selective for DR5 and other therapeutic agents

An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, ar...

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Main Authors KIMBERLY ROBERT P, ZHOU TONG, KOOPMAN WILLIAM J, OHSUMI JUN, ICHIKAWA KIMIHISA, LOBUGLIO ALBERT F, BUCHSBAUM DONALD J
Format Patent
LanguageEnglish
Published 27.04.2010
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
AbstractList An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
Author KOOPMAN WILLIAM J
ZHOU TONG
LOBUGLIO ALBERT F
ICHIKAWA KIMIHISA
BUCHSBAUM DONALD J
KIMBERLY ROBERT P
OHSUMI JUN
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– fullname: LOBUGLIO ALBERT F
– fullname: BUCHSBAUM DONALD J
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Snippet An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title Combinations of antibodies selective for DR5 and other therapeutic agents
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