DNA-PK inhibitors

Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C( O), CH2 and NH are disclosed for use in...

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Main Authors CALVERT HILARY ALAN, CURTIN NICOLA JANE, HUMMERSONE MARC GEOFFREY, MENEAR KEITH ALLAN, GRIFFIN ROGER JOHN, NEWELL DAVID RICHARD, FRIGERIO MARK, SARAVANAN KAPPUSAMY, SMITH GRAEME CAMERON MURRAY, COCKCROFT XIAO-LING, MARTIN NIALL MORRISON BARR, GOLDING BERNARD THOMAS, HARDCASTLE IAN ROBERT, MURR MARINE DESAGE-EL
Format Patent
LanguageEnglish
Published 13.04.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C( O), CH2 and NH are disclosed for use in inhibiting DNA-PK.
Bibliography:Application Number: US20060403606