High purity butoconazole nitrate with specified particle size and a process for the preparation thereof

One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are below 75 mum by diameter, whereas at least 99% of the particles are below 250 mum by diameter, and pro...

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Bibliographic Details
Main Authors DOBAY LASZLO, WERKNE PAPP EVA, SEBOK FERENC, CZIBULA LASZLO, NAGYNE BAGDY JUDIT
Format Patent
LanguageEnglish
Published 01.12.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are below 75 mum by diameter, whereas at least 99% of the particles are below 250 mum by diameter, and process for its preparation. A pharmaceutical composition comprising as active ingredient, high purity butoconazole nitrate of specified particle size in admixture with known auxiliaries is also within the scope of the invention.
Bibliography:Application Number: US20050584662