Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV

• Main Authors: CAMPBELL DAVID ALAN, WINN DAVID T, BETANCORT JUAN MANUEL
• Format: Patent
• Language: English
• Published: 18.08.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV (DPP-IV) inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV...