Diphenylimidazopyrimidines as inhibitors of beta-secretase

The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit beta-secretase (BACE) and treat beta-amyloid deposits and neurofibrillary tangles.

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Bibliographic Details
Main Authors ERDEI JAMES JOSEPH, NOWAK PAWEL WOJCIECH, MALAMAS MICHAEL SOTIRIOS, GUNAWAN IWAN SUWANDI, HARRISON BOYD LYNN
Format Patent
LanguageEnglish
Published 21.07.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit beta-secretase (BACE) and treat beta-amyloid deposits and neurofibrillary tangles.
Bibliography:Application Number: US20060332732