Substituted acylhydroxamic acids and method of reducing TNFalphalevels

• Main Authors: HUANG SHAEI Y, MAN HON-WAH, MULLER GEORGE W
• Format: Patent
• Language: English
• Published: 18.03.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Imido and amido substituted acylhydroxamidic acids which reduce the levels of TNFalpha and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propandylamino)propanoate.