Crystalline forms of carbapenem antibiotics and methods of preparation

• Main Authors: BRANDS KAREL M. J, WILLIAMS JOHN M, FISHER ELIZABETH S, CVETOVICH RAYMOND, WARD MICHAEL D, CROCKER LOUIS S, ORELLA CHARLES, JOBSON RONALD, MAHAJAN AMAR J, WENSLOW ROBERT M, SIDLER DANIEL R
• Format: Patent
• Language: English
• Published: 05.12.2006
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containin...