Crystalline forms of carbapenem antibiotics and methods of preparation
A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containin...
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| Main Authors | , , , , , , , , , , |
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| Format | Patent |
| Language | English |
| Published |
05.12.2006
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| Online Access | Get full text |
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| Abstract | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C. |
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| AbstractList | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C. |
| Author | WARD MICHAEL D CVETOVICH RAYMOND WILLIAMS JOHN M JOBSON RONALD BRANDS KAREL M. J FISHER ELIZABETH S WENSLOW ROBERT M MAHAJAN AMAR J CROCKER LOUIS S SIDLER DANIEL R ORELLA CHARLES |
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| Snippet | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to... |
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| Title | Crystalline forms of carbapenem antibiotics and methods of preparation |
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