Biphenyl derivatives
A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof:wherein R1, R2, R3, R4, and R5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due...
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Main Authors | , , , , , , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
28.08.2001
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Abstract | A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof:wherein R1, R2, R3, R4, and R5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism. |
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AbstractList | A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof:wherein R1, R2, R3, R4, and R5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism. |
Author | MACHIDA YOSHIMASA UENO MASATAKA NAGAOKA ATSUSHI HIGURASHI KUNIZO KOMATSU YUKI SHIMOMURA NAOYUKI KOMATSU MAKOTO UENO KOHSHI YAMANISHI YOSHIHARU MINAMI NORIO NAGATO SATOSHI YONAGA MASAHIRO KAJIWARA AKIHARU KITAZAWA NORITAKA AKASAKA KOZO SHIMIZU TOSHIKAZU |
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Notes | Application Number: US19980166229 |
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Snippet | A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof:wherein R1, R2, R3, R4, and R5 are defined in the... |
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SubjectTerms | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | Biphenyl derivatives |
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