Antisense oligonucleotide modulation of human protein kinase C-delta expression

Compositions and methods are provided for modulating the expression of PKC-delta and for the treatment and diagnosis of diseases associated with protein kinase C-delta. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C-delta expres...

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Bibliographic Details
Main Author DEAN NICHOLAS M
Format Patent
LanguageEnglish
Published 22.05.2001
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:Compositions and methods are provided for modulating the expression of PKC-delta and for the treatment and diagnosis of diseases associated with protein kinase C-delta. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C-delta expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC-delta are disclosed. Methods of modulating the expression of TNF-a using the compositions of the present invention are also provided.
Bibliography:Application Number: US19990313930