Chip for use in nucleic acid separation, structural element and process for forming the structural element

• Main Authors: ENDO; YOSHISHIGE, YOSHIMURA; YASUHIRO, YOKOYAMA; TETSUO, TERAYAMA; TAKAO, YASUDA; KENJI, AONO; TAKANORI, IKEDA; YUKIKO, SAKURAI; TOSHINARI
• Format: Patent
• Language: English
• Published: 19.12.2000
• Edition: 7
• Subjects: CHEMICAL COMPOSITION OF GLASSES, GLAZES, OR VITREOUSENAMELS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; DERIVATIVES THEREOF; GLASS; JOINING GLASS TO GLASS OR OTHER MATERIALS; METALLURGY; MINERAL OR SLAG WOOL; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; SEPARATION; SUGARS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS,MINERALS OR SLAGS; SURFACE TREATMENT OF GLASS; THEIR RELEVANT APPARATUS; TRANSPORTING

Composite particles formed from resin particles and silica particles (amount of silica particles: 0.2 to 10 wt. % on the basis of the resin particles) in an apparatus for formation of composite particles are placed in a PTFE mold and heat treated to weld the resin particles to one another, thereby forming a structural element, which is dipped in an ethyl silicate solution containing monodispersed silica particles, then taken out of the solution and subjected to further heat treatment to form an ultimate structural element, which is sealed in a tip case, whereby a tip can be produced at a low cost and used to separate nucleic acid from a liquid sample for a short time at a high recovery rate without any defects such as breaking, etc.