2-amino-benzoxazinones for the treatment of viral infections

• Main Authors: LI; HUI, FLYNN; DANIEL L, NOSAL; ROGER A, BAX; BRIAN M, SCHRETZMAN; LORI A, VILLAMIL; CLARA I, ABOOD; NORMAN ANTHONY, BECKER; DANIEL P
• Format: Patent
• Language: English
• Published: 16.11.1999
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula II wherein R28 is selected from (a) amino substituted with one or two radicals selected from alkyl, aralkyl, heterocycoalkyl, heterocyclo, and aryl, and (b) amino acid residues and derivatives thereof; wherein R29 is selected from hydrido, alkyl, halo, wherein R30 is selected from alkyl, alkoxy, alkylamino, carboxyalkyl, alkoxyalkyl, alkylaminoalkyl, cycloalkyl, heterocyclo, heterocycloalkyl, heterocycloalkoxy, alkylaminoalkoxy, alkylaminoalkylamino, heterocycloalkylamino, and N-aralkylamino; wherein R31 is alkyl; wherein R32 is alkyl and aryl; or a pharmaceutically-acceptable salt thereof.