1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists

• Main Authors: VEENSTRA; SIEM JACOB, GERSPACHER; MARC, OFNER; SILVIO, SCHILLING; WALTER, ROGGO; SILVIO, AUBERSON; YVES, VON SPRECHER; ANDREAS, MAH; ROBERT, BETSCHART; CLAUDIA
• Format: Patent
• Language: English
• Published: 27.07.1999
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PCT No. PCT/EP96/00555 Sec. 371 Date Aug. 21, 1997 Sec. 102(e) Date Aug. 21, 1997 PCT Filed Feb. 9, 1996 PCT Pub. No. WO96/26183 PCT Pub. Date Aug. 29, 19961-Aryl-2-acylaminoethane compounds of formula I wherein R1-R4, X and Am are as defined in the description, have valuable pharmaceutical properti...