Method for influencing beta -lactam antibiotic production and for isolation of large quantities of ACV synthetase

• Main Authors: BARREDO; JOSE LUIS, PALISSA; HARRIET, MONTENEGRO PRIETO; EDUARDO, VAN LIEMPT; HENK, MARTIN; JUAN FRANCISCO, GUTIEREZ; SANTIAGO, GARCIA; BRUNO DIEZ, VON DOEHREN; HANS, VEENSTRA; ANNEMARIE
• Format: Patent
• Language: English
• Published: 16.03.1999
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Novel methods and compositions are provided for the enhanced production of beta -lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P. chrysogenum and A. chrysogenum delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetase genes have been isolated...