Use of imidazopyrazole derivatives as analgesics anti-inflammatory agents

• Main Authors: WACHI; KAZUYUKI, HASEGAWA; KAZUO, MIYAZAWA; HACHIO, TERADA; ATSUSUKE, IIZUKA; YOSHIO, TABATA; KEIICHI
• Format: Patent
• Language: English
• Published: 16.12.1997
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Described herein are compounds of formula (I): (I) [in which: R1 and R2 are hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, aralkyl, arylalkenyl, aryl, aromatic heterocyclic, cyano or halogen; R3 is hydrogen, optionally substituted alkyl, aralkyl or acyl; R4 and R5 are hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, aralkyl, arylalkenyl, aryl or aromatic heterocyclic]; and pharmaceutically acceptable salts thereof are analgesics and anti-inflammatory agents as well having anti-ulcer and 5-lipoxygenase inhibitory activities. Described herein are compounds of formula (I): (I) [in which: R1 and R2 are hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, aralkyl, arylalkenyl, aryl, aromatic heterocyclic, cyano or halogen; R3 is hydrogen, optionally substituted alkyl, aralkyl or acyl; R4 and R5 are hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, aralkyl, arylalkenyl, aryl or aromatic heterocyclic]; and pharmaceutically acceptable salts thereof are analgesics and anti-inflammatory agents as well having anti-ulcer and 5-lipoxygenase inhibitory activities.